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Opicinumab (anti-LINGO-1)
Opicinumab (also known as anti-LINGO-1 and BIIB033) was an experimental drug investigated as a treatment to promote myelin repair in multiple sclerosis. Clinical studies were halted in 2020.
Information - A-Z
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Imipramine (Tofranil)
Imipramine is a drug used to treat depression. In multiple sclerosis (MS), it is sometimes used to treat pain, particularly nerve pain or altered sensations. It can also be used for some mild bladder symptoms.
Information - A-Z
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Co-morbidity
Co-morbidity means having more than one disease or condition at the same time. Co-morbidities are common among people with MS.
Information - A-Z
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Relaxation
Carrying out relaxation techniques can help bring many health benefits, especially if you live with MS. They can help generate a feeling of peace and calm if you're feeling anxious, stressed or overwhelmed.
Information - A-Z
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Dental fillings
There have been some claims that mercury leaking from the dental amalgam used in fillings damages the immune system and can cause or worsen MS. Learn more in this A-Z entry.
Information - A-Z
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Managing work and study
Want to find out more about working and studying with multiple sclerosis (MS)? This page has links to information on working and studying with MS.
Information - MS information
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MS Decisions aid
Compare the different types of disease modifying drugs (DMDs) that are available to treat multiple sclerosis (MS).
Information - Drug tool
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Dysarthria
Dysarthria is a speech disorder that can occur in multiple sclerosis. It is caused by weakness or lack of coordination in the muscles used in speaking.
Information - A-Z
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Orelabrutinib
Orelabrutinib is a Bruton's tyrosine kinase inhibitor (BTKi) being tested as a new treatment for relapsing remitting multiple sclerosis (MS).
Information - A-Z
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MS information & support
About MS
What is MS?
Types of MS
Causes of MS
How common is multiple sclerosis?
MS research
Newly diagnosed
Young people and MS
Living with advanced MS
Symptoms & diagnosis
Worried you have MS?
Signs and symptoms
How is MS diagnosed?
What's causing my symptoms?
Managing relapses
Drugs & treatments
How is MS treated?
Disease modifying drugs (DMDs)
MS Decisions
Drugs in development
Treatment finder
Non-drug therapies
Health & wellbeing
Thinking and memory problems
Staying Smart
Exercise
Diet and MS
Wellbeing
Family, care & money
Relationships and family life
Care and carers
Home and travel
Work, money and legal
Support & services
Contact our MS helpline
MS services near me
My MS expert
Order a free MS publication
Listen to our podcast
Join our Facebook group
Find support groups
A-Z of MS
What we do
About us
Who we are
Our story
Our directors
Our trustees
Our research and reports
How we are funded
History of MSRTE
Contact us
Get involved
Donate
Donate to the MS Trust
Request to increase your regular donation
Thank you for requesting to increase your Direct Debit
Make a donation
Make a regular donation
Donate in memory
Other ways to donate
Gift Aid
Fundraise
MS Trust Exclusives
Do it your way
Trekking and walking events
Running events
Cycling events
Daredevil events
Fundraise while you shop
Get your fundraising guide
Pay in your fundraising
Raise awareness
Bring Your MS to Work
World MS Day 2026
MS Awareness Week 2026
Volunteer
Leave a gift in your will
Corporate fundraising
Corporate giving
Payroll giving
Pharmaceutical and other industry supporters
News & stories
Latest news & stories
Keep up to date
Sign up for updates
Update your address
Send us your story
For health professionals
Resources
Clinical learning
Professional development
Service development
Courses & training
Funding your learning
MS Trust conference
Development Module
Study days
External courses
Therapists in MS (TiMS)
About TiMS
Meet the TiMS working group
TiMS resources
TiMS newsletters
Join the TiMS network
Order publications
Latest
Latest news for HPs
Keep in touch
MS in Practice
Programmes
Advanced MS Champions programme
Case studies
MS Forward View
Shop