Kalawalla is the brand name of an herbal supplement derived from a type of fern native to Central and South America.

Unsupported claims about the remedial effects of Kalawalla in the treatment of multiple sclerosis suggest that its anti-inflammatory and antioxidant properties regulate the immune system. However, such claims need to be treated with caution as there is no research evidence supporting the use of Kalawalla in MS.

The active ingredient of Kalawalla is Polypodium leucotomos. Where Polypodium leucotomos has been the subject of research studies, the focus has been on the photoprotective properties of the substance and its usage in the treatment of various skin complaints such as psoriasis and light sensitivity.

The risks and benefits associated with the use of Kalawalla in MS have not been fully evaluated.

Find out more

Gomes AJ, et al.
The antioxidant action of Polypodium leucotomos extract and kojic acid: reactions with reactive oxygen species.
Brazilian Journal of Medical and Biological Research 2001;34(11):1487-1494.
Full article (link is external)
Kohli I, et al.
The impact of Polypodium leucotomos on ultraviolet B response: a human clinical study.
Journal of the American Academy of Dermatology 2017; Mar 21 [Epub ahead of print]
Summary (link is external)