Lemtrada can be prescribed for adults with very active relapsing remitting MS. This means that you have relapsing remitting MS that is highly active while taking another disease modifying drug or that your MS is worsening rapidly.
Lemtrada has been approved for use on the NHS since 2014. It can only be prescribed by a neurologist.
You should not take Lemtrada if you have severe active infections, uncontrolled high blood pressure, a history of serious cardiovascular or blood clotting problems, or other autoimmune diseases.
Conception and pregnancy
Pregnancy is not recommended during treatment with Lemtrada. If you plan to start a family discuss your specific circumstances with your MS team.
Women of child-bearing age must use effective contraception during and for four months after a treatment course.
How do I take Lemtrada?
You take Lemtrada as two treatment courses of intravenous (iv) infusions.
the first course consists of iv infusions on five consecutive days
the second course is taken 12 months later and consists of iv infusions on three consecutive days
In general you will be admitted as a hospital inpatient for the duration of each treatment course.
Most of the people who took Lemtrada in large clinical studies did not require additional treatment courses. On-going studies are monitoring the requirement for retreatment in subsequent years.
infusion-related reactions such as headache, rashes, fever and nausea.
Most people treated with Lemtrada are affected by these reactions but they are generally mild to moderate and short-lived. To minimise infusion-related reactions, additional medications are given before infusions
infections including coughs, colds, chest infections and herpes virus infections (such as cold sores or shingles)
Lemtrada suppresses the immune system for some time after a treatment course so people will be more vulnerable to infections such as colds and viruses. To reduce the risk of herpes infections, an antiviral medication should be taken starting from the first day of infusion and continued for at least one month. Your MS team should give advice on other ways to minimise the risk of infections, including avoidance of foods that may be a source of the bacteria, Listeria. As a precautionary measure, they may also recommend that you take antibiotics before and after your treatment courses.
Three serious side effects have been reported from clinical trials
overactive or underactive thyroid gland leading to thyroid disorders
idiopathic thrombocytopenic purpura (ITP), a serious disorder which prevents blood from clotting
These side effects are potentially serious but are treatable if caught early enough. People taking Lemtrada will be informed of the early signs and symptoms of these side effects.
Other very rare but serious side effects have been reported from patient experience
Serious disorders affecting the heart and blood vessels leading to possible bleeding or stroke. These may occur shortly after a Lemtrada infusion.
Serious autoimmune disorders that may arise many months or years after the last treatment.
Common side effects (affecting more than 1 person in 100)
overactive or underactive thyroid
infusion associated reactions including headaches, rashes, fever and nausea
infections - respiratory and urinary
decrease in white blood cells (lymphopenia)
changes in blood pressure, heart rate
Less common side effects (affecting less than 1 person in 100)
idiopathic thrombocytopenic purpura (ITP) a blood clotting disorder
Before starting Lemtrada, you should have blood and urine tests to measure blood cell counts and to check the function of the thyroid gland and kidneys. You should also be tested for immunity against the virus that causes chickenpox and offered vaccination if you have not previously been exposed to the virus. Having live or live-attenuated vaccines is not recommended if you are taking Lemtrada, so you should consider having any vaccines you need for work or travel at least 6 weeks before you start Lemtrada.
Assessment during treatment
Because of the serious nature of the potential side effects, it is vital that you have monthly blood and urine tests for four years after your last treatment course to monitor blood cell counts and to check the function of the thyroid gland and kidneys. Depending on local practice, tests may be carried out at a local GP surgery or it may be necessary to attend a hospital clinic.
During the coronavirus outbreak, you may find that your regular blood tests happen less frequently, may take place in a different location or may temporarily stop. The Association of British Neurologists has assessed the risks and benefits of blood monitoring for people taking DMDs, and has recommended a safe minimum schedule during this period. The recommendation for Lemtrada is that you can move to having your tests every three months, so long as you are stable. If you notice any new or worsening MS symptoms, you should contact your MS team immediately.
How does Lemtrada work?
Lemtrada works by binding to and killing immune cells (lymphocytes or white blood cells) which are involved when the immune system attacks myelin. It is thought that the immune cells which grow back after treatment do not cause damage to nerves.
What are the results so far?
Evidence for the effectiveness of Lemtrada has come from two large studies.
CARE-MS I - Lemtrada compared to Rebif in people who had not been treated with a DMD
This two year study compared Lemtrada and Rebif in 581 people in the first few years after diagnosis with relapsing remitting MS who had not been treated with a DMD. Lemtrada reduced relapses by 55% compared to Rebif. There was no significant difference in disease progression between the two groups.
CARE-MS II - Lemtrada compared to Rebif
This two year study compared Lemtrada and Rebif in 667 people who had had at least one relapse while taking a DMD. Lemtrada reduced relapses by 49% compared to Rebif. The risk of disease progression was also reduced by 42% compared to Rebif, with 20% of the Rebif group showing an increase in disability compared to 13% of the Lemtrada group.
What further research is planned?
CAM-THY - Prevention of autoimmunity after Lemtrada treatment
Lemtrada works by binding to and killing T-cells (lymphocytes). 1 in 5 people develop an autoimmune disease after treatment; as their immune system grows back, it begins to attack other parts of their body, most commonly the thyroid gland. This trial will attempt to reduce the risk of autoimmune disease after treatment with Lemtrada by combining it with a second drug which alters the way in which the immune system grows back. Palifermin works by boosting the function of the thymus, a gland in the neck which makes new immune cells.
Estimated completion date October 2017. This study has now stopped as an interim analysis failed to show a benefit of palfermin.
National Institute for Health and Care Excellence (NICE). Alemtuzumab for treating relapsing-remitting multiple sclerosis [TA312]. NICE Technology Appraisal Guidance 312. Full guideline (link is external)
Cohen JA, et al. Alemtuzumab versus interferon beta 1a as first-line treatment for patients with relapsing-remitting multiple sclerosis: a randomised controlled phase 3 trial. Lancet 2012;380:1819-28. Summary (link is external)
Coles AJ, et al. Alemtuzumab for patients with relapsing multiple sclerosis after disease-modifying therapy: a randomised controlled phase 3 trial. Lancet 2012;380:1829-39. Summary (link is external)
On this page
Disease modifying drugs: an introduction - information sheet
If you are newly diagnosed and experiencing relapses, you may be considering treatment with one of the disease modifying drugs. This short guide explores the range of drugs that can decrease the number and severity of relapses.